The Regional Integrated Environmental Model System (RIEMS 2.0) coupled with a chemistry-aerosol model and the Princeton Ocean Model (POM) is employed to simulate regional oceanic impact on atmospheric circulation and the direct radiative effect (DRE) of aerosol over East Asia. The aerosols considered in this study include both major anthropogenic aerosols (e.g., sulfate, black carbon, and organic carbon) and natural aerosols (e.g., soil dust and sea salt). The RIEMS 2.0 is driven by NCEP/NCAR reanalysis II, and the simulated period is from 1 January to 31 December 2006. The results show the following: (1) The simulated annual mean sea-level pressure by RIEMS 2.0 with POM is lower than without POM over the mainland and higher without POM over the ocean. (2) In summer, the subtropical high simulated by RIEMS 2.0 with POM is stronger and extends further westward, and the continental low is stronger than without POM in summer. (3) The aerosol optical depth (AOD) simulated by RIEMS 2.0 with POM is larger in the middle and lower reaches of the Yangtze River than without POM. (4) The direct radiative effect with POM is stronger than that without POM in the middle and lower reaches of the Yangtze River and parts of southern China. Therefore, the authors should take account of the impact of the regional ocean model on studying the direct climate effect of aerosols in long term simulation.