The Infrared Atmospheric Sounding Interferometer (IASI) is a new-generation ultraspectral atmospheric sounding instrument mounted on the MetOp-A, the first operational polar-orbiting satellite developed by the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT). It is an ultrahigh spectral-resolution atmospheric detector which can detect atmospheric chemical composition, temperature, and humidity profiles with high accuracy and resolution. In the present study, through comparative analyses of the similarities and differences between the IASI and the radiosonde observation (RAOB) water vapor data, and between the IASI and the Aqua-AIRS water vapor retrievals, a detailed and systematic assessment of the credibility of the IASI water vapor retrievals over the plateau region was made. A comparison of the IASI retrievals with the AIRS retrievals and the RAOB measurements over the Tibetan Plateau revealed that the IASI retrieval data are reliable and can be used for conducting further studies.